- Jeff Gordon - I think this is his year and he's already proved he has a strong car.
- Kevin Harvick - He's really grown to be a great super-speedway racer. I think he could certainly be a threat to win the 500 again.
- Mark Martin - More Hendrick power here. I think he'll be in the lead often, but I don't know if he can actually tie this one down.
- Clint Bowyer - The Kansas native seems to have learned quickly from his teammates and after the Nationwide race should really prove to be a threat.
- Dale Earnhardt, JR - You can't ever count out this guy on a Super-Speedway, especially boasting Hendrick horsepower.
- Jamie McMurray - He's won here under the lights and although he may be an underdog, I expect him to be strong if he can stay out of trouble.
- David Ragan - With all the improvement he showed last season, he very well may start this season off strong.
- Kyle Busch - He's daring and doesn't mind putting his car in places others won't go. Problem is this is a double-edged sword at Daytona.
- Tony Stewart will have to fight from the back after moving to a back-up, regardless, the man knows the way around The World Center of Racing.
- Carl Edwards - Roush-Fenway has been OK on Super-Speedways as of late, if not Edwards then Biffle.
Dark Horses:
- Casey Mears - The 07 team knows what to do. Mears has plenty of experience but no results to show for it. Assuming he can dodge the mis-haps look for him to challenge for a top-5 position.
- Jeff Burton - Although he may not be aggressive enough to really dominate a race like this, the skillful veteran could definitely be left standing at the end to challenge for a win
- Bill Elliott - Great car, great experience. Sounds like the possibility of a win to me.
- Michael Waltrip - This is someone who knows this Florida speedway very well. Toyota has the horsepower, but Waltrip may or may not have the talent left in him.
- Brian Vickers - his lone Cup win came at Talladega, He's matured as a driver since then and with Team Red Bull his chances this season of being in contention for many races are quite high.
- DT